Orrego-Savala is facing four felony counts stemming from the Sunday crash.
According to the Indiana State Police Department (h/t ESPN.com's Mike Wells), Jackson and Jeffery Monroe were killed early Sunday morning after they were struck by a vehicle being driven by a man suspected of drunken driving on Interstate 70 in Indianapolis.
One of the men was thrown into the center lane.
The fatalities come about two months after a California jury acquitted a Mexican man in the fatal July 2015 shooting of a woman on a San Francisco pier - a death that touched off a fierce national immigration debate.
"I think we recognize that this was a tremendous tragedy, offer our condolences, respect and support and use this opportunity to bring people together", said Rep. Carson. Trump made no aggressive claims to improve domestic gun control laws and simply said, "My warmest condolences and sympathies to the victims and families of the awful Las Vegas shooting".
The affidavit said Orrego-Savala has had prior run-ins with law enforcement for driving without a valid license and that he was walking away from the crash scene when an IN state trooper detained him.
Jeffrey had been an Uber driver for more than two years and his wife says he loved every minute of it. Another court hearing was scheduled for Wednesday.
The judge entered a not guilty plea on his behalf and set bond at $200,000.
FOX 59 reached out to immigration defense attorney Sarah Burrow to discuss what happens next in case where a suspect faces both local charges and possible action by ICE.
Outside the courtroom, defense attorney Jorge Torres said he had "serious concerns" about getting a fair trial in light of the negative attention on his client's immigration status. He notes that Orrego-Savala has been living in IN for several years and doing construction work in the Indianapolis area.
"He's very distraught to say the least", Torres said.
"The family is in shock, as you can imagine".
Prosecutors allege Orrego-Savala was driving the vehicle that crashed into Jackson and Monroe as the two men stood outside Monroe's auto early Sunday along Interstate 70 in Indianapolis.
Investigators believe that Monroe was a ride-sharing operator who pulled to the side of the road and got out of the auto to assist Jackson, 26, who became ill.
Orrego-Savala was arrested following the crash early Sunday along Interstate 70 in Indianapolis. Police said 37-year-old Manuel Orrego-Savala, whose blood-alcohol level was almost three times the legal limit, fatally struck them.
Added Steve Doocy: "He was deported twice".
He was convicted of driving under the influence in Redwood City, Calif., in 2005, Alberico said.
He's being held in Marion County Jail. Much of Orrego-Savala's background, including how much time he spent in Guatemala, is unknown at this point. Federal prosecutors spell his name as Orrego-Zavala, but the federal criminal compliant lists "Orrego-Savala" as among his aliases.
Orrego-Savala's only responses in court were answering through an interpreter as the judge explained the proceedings and charges. "I don't know why I am here", he was quoted as saying by WIBC.
A police news release did not mention the presence of anyone else in the pickup truck.
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