Officers were unable to stop the fighting and secure the prison until around 2:55 a.m. on Monday.
The South Carolina Department of Corrections says the incident started at 7:15 p.m. on Sunday and it involved multiple inmate on inmate altercations in three housing units.
Lee Correctional houses about 1,500 inmates, some of South Carolina's most violent and longest-serving offenders.
Of South Carolina's nine all-male, maximum-security prisons, Lee Correctional Institution is the largest. Lee County Fire reports on Twitter that crews responded to a "mass casualty incident" and were assisted by Florence County EMS, Kershaw County EMS, Darlington County EMS, Lexington County EMS and Hartsville Rescue.
Emergency services from neighboring SC counties responded to the incident.
No additional details were immediately provided on the cause of the incident at the prison.
In March, inmates at the prison held an officer hostage after taking control of a dorm room, The State reported.
In February, an inmate was killed by another inmate in a fight.
According to the agency, all staff and responding law enforcement officers were "safe and accounted for".
Ryan Gaydos is an editor for Fox News.
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