They added two more runs in the second inning and knocked White Sox starting pitcher Reynoldo Lopez from the game.
The Pirates jumped all over the White Sox early in their series opener Tuesday night at PNC Park, but all the news wasn't good for the home side.
Williams (5-2) struck out six and walked none in his longest outing of the season. Both have been among the Pirates best hitters to start the season, with both batting over.300.
Marte is hitting.308 with six home runs and 19 RBIs.
Sox: Second baseman Yoan Moncada (left hamstring tightness) was activated from the disabled list and went 1 for 4. He had been out since May 4.
The Pirates characterized Marte's departure as right side discomfort. His only other career appearance against the Pirates was a start in 2016, when he gave up four hits and three runs in four innings and did not get a decision. Catcher Francisco Cervelli left the game at the end of the third inning with right forearm discomfort.
In a couple of starts earlier this month, Santiago put up 10 earned over 8.0 innings on 11 hits.
Sox: Left-hander Hector Santiago (0-1, 5.60 ERA) will make a spot start Wednesday in the series finale. Chicago is also 17-38 in their last 53 road games and 8-20 in Santiago's last 28 starts. He'll be replacing right-hander Carson Fulmer, whose scheduled start was pushed back to Saturday.
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