Ho-hum. It's another Wimbledon quarterfinal appearance for Roger Federer, who seeks a fifth straight and 13th overall trip to the semifinals at the All-England Club when he takes on No. 8 seed Kevin Anderson on Wednesday in London.
The eight-time champion was two sets up and had a match point in the third, but nearly three hours later he trudged off on the end of a seismic 2-6 6-7 (5/7) 7-5 6-4 13-11 upset.
Djokovic, a three-time Wimbledon champion, maintained the dominance on Center Court that he has shown throughout the tournament on his first serve.
This was Federer's earliest departure from Wimbledon since his shock second round defeat against Sergiy Stakhovsky in 2013. That's the mindset you need against someone like Roger.
The first set between Federer and Mannarino was so one-sided that, when Mannarino trailed 0-40 in the opening game of the second, the normally pro-Federer Centre Court crowd began to cheer loudly for his opponent.
The world No 1 said: "Of course it's an important result for me". The eighth seed sprung a surprise with a 2-6, 6-7 (5), 7-5, 6-4, 13-11 victory.
Many are already anticipating a Sunday final between Federer and Nadal, 10 years after their 2008 epic championship showdown widely regarded as the greatest final ever played.
In their four previous meetings Anderson, 32, had not taken a set off Federer. Nishikori and John Isner are both through to the quarter-finals for the first time.
A Federer double fault at 11-11 in the fifth opened up the door to the lone break of the decider and Anderson closed it out with a massive serve to reach a first Wimbledon semifinal.
Kevin Anderson, left, rallied from two sets down to deny Roger Federer's bid to win his ninth Wimbledon title this year. "Beating Roger Federer here at Wimbledon will definitely be one that I remember - especially in such a close match".
Federer eventually stemmed the tide with a love hold, and the set was back on serve when Anderson failed to clear the tape with a forehand after saving two break points. Federer is now 266-3 after winning the first two sets.
The last time he won as many consecutive sets was in 2005 and 2006 at the height of his dominance.
Djokovic has had a hard two years but is beginning to look and feel a lot more like his old self again.
Federer hasn't dropped serve at Wimbledon so far but is wary of the challenge posed by Anderson whose big serving style is flourishing on courts cooked by last week's heatwave.
"I think Rafa and Del Potro had to be on Centre Court", Murray told BBC.
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